Police have confirmed eight people have died following a major collision on the southbound M1 motorway near Newport Pagnell in Buckinghamshire.
The accident happened at 3:15 a.m BST and involved two lorries and a minibus, according to a police statement.
Four other people, including a child, were injured and taken to hospital.
Thames Valley Police said on Twitter the vehicles were all traveling in the same direction and it’s thought the minibus had come from the Nottingham area.
All eight victims were on board the minibus. Both lorry drivers survived.
Two men have been arrested on suspicion of causing death by dangerous driving and both are currently in custody.
One, a 31-year-old from Worcestershire, is suspected of having been over the alcohol limit at the time of the crash, The Independent reports.
One of the lorries belonged to courier company FedEx, who told The Independent: "We are aware of the tragic accident that occurred last night on the M1 motorway, junction 14 in the UK with a FedEx truck involved.
"Our deepest thoughts and concerns are with all of those involved.
"Safety is of the utmost importance to FedEx, and we are cooperating fully with authorities but have no further information at this time."
The southbound carriageway between Milton Keynes and Northampton has since reopened.
Police are appealing to anyone who witnessed the collision and has not yet spoken to officers to contact Thames Valley Police.